Fenofibrate Characterization of Solid Lipid Nanoparticles Using the High Shear Homogenization Method

Fenofibrate is a drug that can be used to treat hyperlipidemia where the included in category of Biopharmaceutical classification system II with poor solubility and high permeability. This causes need improve delivery (DDS) made using solid lipid nanoparticle (SLN) method. SLN fenofibrate shear homogenization method by determining formula Factorial 22 Design Expert 12. The concentration 0.31-1.25% GMS 1.25-2% Tween-40, then mixing all ingredients until an emulsion formed continued critical parameter test. From test results, parameters for particle size 8 formulas 490; 561; 601; 697; 916; 1040; 1818, 2410 nm. results obtained polydispersity index, respectively, were 0.02; 0.04; 0.08; 0.30; 0.35; 0.48; 0.51, 0.65. zeta potential value successive values 2.8; 3.5; 4.2; 4.8; 5.5; 5.8; 8.1, 8.8 mV. Calculation efficiency 77.23; 78.53; 79.51; 80.47; 81.17; 87.38; 87.39, 87.82%. drugs are class distribution range, adsorbed more than 70%.